Platelet-rich plasma (PRP) has emerged as a promising solution for skin rejuvenation and hair loss in dermatology and aesthetic treatments. The last five years have witnessed a surge in publications supporting PRP's effectiveness in treating alopecia, gaining recognition in evidence-based guidelines. This blog will explore the science behind PRP, Growth Factor Concentrate (GFC), and microneedling, exploring their efficacy and potential synergies.
Platelet-Rich Plasma (PRP):
PRP is an autologous concentration of platelets in the blood plasma fraction, obtained through differential centrifugation. It has gained popularity as a safe, office-based procedure to improve hair growth in Androgenetic Alopecia (AGA). AGA, a genetic and hormonal-influenced non-scarring hair loss, affects both genders and often leads to psychosocial distress.
The hair growth cycle is regulated by various growth factors (GFs) stored in platelet alpha granules, including Platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), transforming growth factor beta (TGF b1 and b2), insulin 1-like growth factor (IGF-1), and fibroblast growth factor (FGF). PRP releases these growth factors upon activation, stimulating molecular pathways that promote hair growth and prevent apoptosis.
Research suggests that PRP, when combined with microneedling, enhances its efficacy. This combination effectively treats AGA, augmenting the effects of conventional therapies like minoxidil and finasteride. However, the assessment of results often relies on global photographs rather than precise hair count.
While PRP with microneedling is generally considered safe with minimal reported side effects, pain during the procedure remains a limitation. Nonetheless, the pain can be managed with topical anesthesia or other methods.
Growth Factor Concentrate (GFC):
GFC, akin to PRP, utilizes growth factors to stimulate hair follicles. Although still a relatively new entrant in the field, preliminary research indicates its potential effectiveness on skin and hair. However, more extensive studies are needed to establish conclusive evidence regarding its efficacy and long-term outcomes.
Microneedling for Hair Loss:
Microneedling, initially renowned as a scar treatment, has garnered attention as a potential treatment for Androgenetic Alopecia and Alopecia Areata. The procedure involves using a skin roller with tiny needles to create micro-injuries on the scalp, stimulating collagen production and blood flow.
When combined with PRP, microneedling becomes a potent tool for stimulating new hair growth. The micro-injuries the needles create increase blood flow to the scalp, providing essential nutrients and oxygen to hair follicles.
Studies have shown promising results, with a 50% increase in hair regrowth in 80% of participants when combining microneedling with minoxidil.
Microneedling not only aids in promoting hair growth but also enhances the absorption of other hair regeneration treatments, including PRP therapy and additional growth factors. However, it's essential to note that microneedling may not be effective in cases of permanent baldness, where an FUE (Follicular Unit Extraction) hair transplant might be the only viable solution.
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So, PRP, GFC, and microneedling stand out as promising options in the ever-evolving landscape of hair restoration treatments. The combination of PRP with microneedling, in particular, shows significant potential in addressing hair loss concerns.
As research continues, individuals seeking hair restoration should remain informed, consulting dermatologists to make well-informed decisions tailored to their needs and conditions.
Yours Truly,
Shweta
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